个人简介
2006年本科毕业于南京大学生物化学系，2011年获美国德克萨斯大学西南医学中心生物化学博士学位。随后在美国麻省总医院从事博士后研究，师从诺贝尔奖获得者Gary Ruvkun教授。她的研究方向为细胞营养感知和代谢应激调控，揭示了细胞感应氨基酸水平的新机制，提出了线粒体监察的新概念，系统解析了线粒体胁迫的应激机制，为细胞信号对生命体的稳态调控提供了新理论，为代谢和衰老相关疾病的治疗提供了重要基础。
入选全国三八红旗手、国家杰出青年、科技创新领军人才、美国霍华德休斯医学研究所(HHMI)国际研究学者、首届新基石研究员；获首届科学探索奖、中国青年女科学家奖、谈家桢生命科学创新奖等。
现任中国细胞生物学学会细胞代谢分会副主任委员、细胞器分会副主任委员，中国生物物理学会代谢分会副主任委员，Springer Nature中国学术咨询委员会委员，Molecular Cell、Life Metabolism、Vita等期刊编委。
教育背景
2002-2006 南京大学 生物技术 学士
2006-2011 美国得克萨斯大学西南医学中心 生物化学 博士
（导师：刘清华教授）
工作经历
2011.8 – 2014.2 美国麻省总医院、哈佛大学医学院博士后
（导师：2024年诺贝尔生理学或医学奖获得者 Gary Ruvkun教授）
2013.12 –2019.8 WilliamHill中文官方网站分子医学研究所 研究员
2019.8 –2021.2 WilliamHill中文官方网站分子医学研究所/william威廉中文官网 长聘副教授
2021.2–2022.9 WilliamHill中文官方网站副院长、教授
2022.9–至今 WilliamHill中文官方网站副院长、人事部副部长、教授
代表性论文
Selected research article:
1. Jiang L, Li L, Guan J, Liu Y*; A transport-independent role for SLC25A12 in mitochondrial stress signaling. Nature Cell Biology (2026) https://doi.org/10.1038/s41556-026-01973-1
2. Zhou L*, Liu Y*; Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism. Cell Research (2026) 36:286-299.
3. Zhou L, Jiang L, Li L, Ma C, Xia P, Ding W, Liu Y*; A germline-to-soma signal triggers an age-related decline of mitochondrial stress response. Nature Communications (2024) 15:8723.
4. Xu C#, Pan X#, Wang D, Guan Y, Yang W, Chen X* and Liu Y*. O-GlcNAcylation of Raptor transduces glucose signals to mTORC1. Molecular Cell (2023) 83:3027-3040.
5. Yan G, Yang J, Li W, Guo A, Guan J and Liu Y*. Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing. Nature Cell Biology (2023) 25:754-764.
6. Wang D#, Xu C#, Yang W, Chen J, Ou Y, Guan Y, Guan J, Liu Y*; E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Molecular Cell 82 (2022) 709-712.
7. Chen J#*, Ou Y#, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen P, Liu Y*. SAR1B senses leucine levels to regulate mTORC1 signalling. Nature (2021) 596(7871):281-284.
8. Li Y, Ding W, Li C-Y and Liu Y*. HLH-11 modulates lipid metabolism in response to nutrient availability. Nature Communications (2020) 11:5959.
9. Shao L-W#, Peng Q#, Dong M, Gao K, Li YM, Li Y, Li C-Y* and Liu Y*. Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications (2020) 11:4639.
7. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife (2019) e41792.
8. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology (2019) 21:319-327.
9. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature (2018) 557:585-589.
10. Chen J#, Ou Y#, Li Y, Hu S, Shao LW and Liu Y*. Metformin extends C. elegans lifespan through lysosomal pathway. eLife 6 (2017) e31268.
11. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Research (2016) 11:1182-1196.
12. Liu Y, Samuel BS, Breen PC and Ruvkun G*. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature (2014) doi:10.1038/nature13204.
13. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q*. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Molecular Cell 44 (2011) 502-508.
14. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q*. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941 (2009) 750-753.
Invited review:
1. Zhou L*, Liu Y*; The trade-off between reproduction and resilience. Trends Endocrinol Metab (2026) 37:107-114.
2. Zhou L*, Liu Y*; Germline regulation of the somatic mitochondrial stress response. Trends Cell Biol (2024) 34:617-619.
3. Liu Y*. Epigenetic codes of mitochondrial homeostasis. Nature Aging 1 (2021) 153-154.
